TREATMENT OF PSEUDOMONAS MENINGITIS WITH CEFTAZIDIME WITH OR WITHOUT CONCURRENT THERAPY

In ongoing studies in Europe and theUnited States, 10 pediatric patients with bacterial meningitis caused by Pseudomona species were treated with ceftazidime.Pseudomonas aeruginosa was isolated from the CSF of 7 patients and other Pseudomonas species from the remaining 3. Eight of the 10 patients had received previous antimicrobial treatment which included aminoglycosides in 6, along with ticarcillin and ureidopenicillins in 3. Ceftazidime was administered 10 to 42 days in dosagesranging from 109 to 300 mg/kg/day. Seven of the 10 patients received ceftazidime only for10 to 42 days. The other 3 patients received amikacin in 2 and gentamicin and tobramycin in the other. © 1990 by Williams and Wilkins.