ANTIASTHMATIC EFFECTS OF ONIONS - INHIBITION OF 5-LIPOXYGENASE AND CYCLOOXYGENASE INVITRO BY THIOSULFINATES AND CEPAENES

被引：50

作者：

WAGNER, H ^{[1
]}

DORSCH, W ^{[1
]}

BAYER, T ^{[1
]}

BREU, W ^{[1
]}

WILLER, F ^{[1
]}

机构：

[1] UNIV FRANKFURT,CHILDRENS HOSP,W-6000 FRANKFURT,GERMANY

来源：

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS | 1990年 / 39卷 / 01期

关键词：

D O I：

10.1016/0952-3278(90)90173-I

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nine thiosulfinates (TS) and four "Cepaenes" (CS) isolated from onions and/or synthetized by us showed dose dependent (0,25 to 100 μM) marked inhibitory effects on both cyclooxygenase (CA, tested on sheep seminal vesicle microsomes) and 5-lipoxygenase activity (LO, tested on porcine leukocytes). The following rank order of activity was observed: saturated aliphatic TS < aromatic TS ≈ α,β-unsaturated TS < CS. CS inhibited both CA and LO by more than 75% at 10 and 1 μM concentrations respectively. Most likely, these in vitro effects are responsible for antiinflammatory and antiasthmatic properties of onion extracts observed in vivo, at least in part. © 1990.

引用

页码：59 / 62

页数：4

共 18 条

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