HYPOTHESIS FOR THE PATHOGENESIS OF SODIUM AUROTHIOMALATE (MYOCRISIN) INDUCED IMMUNE-COMPLEX NEPHRITIS

被引：15

作者：

SKRIFVARS, B

机构：

[1] IV Department of Medicine, Helsinki University Central Hospital, Helsinki

来源：

SCANDINAVIAN JOURNAL OF RHEUMATOLOGY | 1979年 / 8卷 / 02期

关键词：

D O I：

10.3109/03009747909105348

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Renal complications associated with gold salt treatment in rheumatoid arthritis occur in fewer than 5 % of treated patients. Recent investigations have shown that the renal lesion manifested clinically as membranous glomerulonephritis is caused by immune complexes. This paper presents a hypothesis for the mechanism by which gold causes this lesion: autoimmunization due to released tubular antigen(s). This hypothetical mechanism is strikingly similar to that responsible for autologous autoimmune nephrosis in the rat (Heymann's nephritis). © 1979 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：113 / 118

页数：6

共 17 条

[1]

DEROT M, 1954, Bull Mem Soc Med Hop Paris, V70, P234

[2] AUTOLOGOUS IMMUNE COMPLEX NEPHRITIS INDUCED WITH RENAL TUBULAR ANTIGEN .I. IDENTIFICATION AND ISOLATION OF PATHOGENETIC ANTIGEN [J].