PHOSPHATIDYLSERINE INCREASES THE AFFINITY OF THE AMPA QUISQUALATE RECEPTOR IN RAT-BRAIN MEMBRANES

被引：33

作者：

BAUDRY, M

MASSICOTTE, G

HAUGE, S

机构：

[1] Program in Neural, Informational, Behavioral Sciences, Los Angeles

来源：

BEHAVIORAL AND NEURAL BIOLOGY | 1991年 / 55卷 / 02期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/0163-1047(91)80134-Z

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

We investigated the effects of phospholipids and cholesterol on the binding of [3H]-AMPA to rat telencephalic membranes. Phosphatidylcholine, phosphatidylethanolamine, sphingomyelin, and cholesterol were without effect at concentrations up to 1.5 mg/mg protein. Only phosphatidylserine increased [3H]-AMPA binding in a dose-dependent manner. This effect was due to an increase in the affinity of the low affinity component of [3H]-AMPA binding. These results indicate that the distribution of phosphatidylserine in membranes modulates the properties of the AMPA/quisqualate receptor. © 1991 Academic Press, Inc.

引用

页码：137 / 140

页数：4

共 5 条

[1]

COTMAN CW, 1989, J NIH RES, V1, P65

[2] BRAIN SPECTRIN, CALPAIN AND LONG-TERM CHANGES IN SYNAPTIC EFFICACY [J].