CARDIOVASCULAR ACTIONS OF MEPTAZINOL IN COMPARISON WITH PENTAZOCINE AND MORPHINE

被引：12

作者：

RASHID, S

WATERFALL, JF

机构：

[1] Wyeth Institute of Medical Research, Maidenhead, England, Huntercombe Lane South, Taplow

来源：

GENERAL PHARMACOLOGY | 1979年 / 10卷 / 06期

关键词：

D O I：

10.1016/0306-3623(79)90009-0

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. In comparative experiments with pentazocine and morphine in anaesthetized cats, the analgesic agent meptazinol (0.1-25.6 mg/kg i.v.) transiently decreased blood pressure, heart rate, left ventricular dp/dt and cardiac effort index. The highest dose was lethal in 2/5 cats. 2. Atropine (1 mg/kg i.v.) attenuated the bradycardia evoked by a single dose of meptazinol (6 mg/kg i.v.) but the hypotensive response was unchanged. 3. Meptazinol (50 mg/kg p.o.) had no significant effects on the blood pressures and heart rates of conscious hypertensive rats. © 1979.

引用

页码：459 / 464

页数：6

共 28 条

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