NEUROADAPTIVE RESPONSES TO CHRONIC ETHANOL

被引：60

作者：

BUCK, KJ

HARRIS, RA

机构：

[1] UNIV COLORADO,HLTH SCI CTR,DEPT PHARMACOL,DENVER,CO 80262

[2] VET ADM MED CTR,DENVER,CO 80220

[3] UNIV COLORADO,HLTH SCI CTR,ALCOHOL RES CTR,DENVER,CO 80262

来源：

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH | 1991年 / 15卷 / 03期

关键词：

ETHANOL; TOLERANCE; GABA; ION CHANNELS; DEPENDENCE;

D O I：

10.1111/j.1530-0277.1991.tb00544.x

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

Cellular responses of neuronal tissue to chronic ethanol exposure are reviewed. Evidence for adaptive responses to the acute actions of ethanol is available for five systems: GABA-activated chloride channels, voltage-sensitive calcium channels, NMDA-activated cation channels, receptors coupled through stimulatory guanine nucleotide binding proteins, and membrane lipid order. We suggest that at least some of these adaptive responses occur because of ethanol actions at the level of gene expression.

引用

页码：460 / 470

页数：11

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