ROLE OF BETA INTERFERON IN RESISTANCE TO TOXOPLASMA-GONDII INFECTION

被引：50

作者：

ORELLANA, MA

SUZUKI, Y

ARAUJO, F

REMINGTON, JS

机构：

[1] PALO ALTO MED FDN,RES INST,DEPT IMMUNOL & INFECT DIS,PALO ALTO,CA 94301

[2] JIKEI UNIV,TOKYO 105,JAPAN

[3] STANFORD UNIV,MED CTR,SCH MED,DEPT MED,DIV INFECT DIS,STANFORD,CA 94305

来源：

INFECTION AND IMMUNITY | 1991年 / 59卷 / 09期

关键词：

HUMAN MACROPHAGES; ALPHA-INTERFERON; GAMMA-INTERFERON; LYMPHOCYTES-T; ANTIGEN; CELLS; ACTIVATION; INHIBITION; BURST;

D O I：

10.1128/IAI.59.9.3287-3290.1991

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The role of recombinant murine beta interferon (rMuIFN-beta) and recombinant human IFN-beta (rHuIFN-beta) in resistance to Toxoplasma gondii was examined. rMuIFN-beta protected mice against a lethal infection with the parasite. The protective effect appeared to depend on the concomitant release of gamma interferon. rMuIFN-beta did not activate murine peritoneal macrophages to inhibit or kill T. gondii whether used alone or in combination with lipopolysaccharide (LPS). rHuIFN-beta did not activate human monocyte-derived macrophages to inhibit or kill T. gondii when 5-day-old monocyte-derived macrophages were used. In contrast, significant killing of T. gondii was noted when 10-day-old monocyte-derived macrophages were used. The addition of LPS enhanced this effect. These results revealed a role for IFN-beta in the mechanisms of defense against T. gondii and suggest its potential use in the treatment of toxoplasmosis in humans.

引用

页码：3287 / 3290

页数：4

共 22 条

[1] EFFECT OF NORMAL AND ACTIVATED HUMAN MACROPHAGES ON TOXOPLASMA-GONDII [J].