INTRATUMOR TREATMENT OF C3H MOUSE MAMMARY-CARCINOMA WITH 5-FLUOROURACIL ADSORBED ON ACTIVATED-CHARCOAL PARTICLES

被引：3

作者：

BONHOMME, L

MATHIEU, MC

AMDIDOUCHE, D

FAURE, E

GUISTEAU, D

FREDJ, G

NAVEAU, S

机构：

[1] INST GUSTAVE ROUSSY,DEPT ANATOMOPATHOL,F-94800 VILLEJUIF,FRANCE

[2] INST GUSTAVE ROUSSY,DEPT ANIMALERIE,F-94800 VILLEJUIF,FRANCE

[3] HOP ANTOINE BECLERE,SERV HEPATOGASTROENTEROL,F-92141 CLAMART,FRANCE

来源：

ANTI-CANCER DRUGS | 1992年 / 3卷 / 03期

关键词：

CHARCOAL SUSPENSION; DRUG DELIVERY SYSTEM; 5-FLUOROURACIL; LOCAL CHEMOTHERAPY;

D O I：

10.1097/00001813-199206000-00009

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A dosage form comprising 5-fluorouracil (5-FU, 25 mg/ml) adsorbed on a suspension of micronized charcoal (100 mg/ml) 2-5-mu-m in diameter, adsorbing 5-FU in aqueous solution was studied for intratumor treatment of mammary carcinoma in animal experiments. An in vitro desorption method is described to determine the amount of 5-FU adsorbed on activated charcoal particles which would be released once the drug concentration decreased around the charcoal. In vivo results indicate that an intratumor injection of 5-FU adsorbed on activated charcoal particles is a highly effective method for achieving tumor regression without increasing toxicity.

引用

页码：261 / 266

页数：6