RELEASE OF MIGRATION INHIBITORY FACTORS FROM IMMUNE RAT LYMPHOCYTES CONFRONTED WITH HISTOCOMPATIBILITY ANTIGENS

RODENT spleen cells migrate from capillary tubes in vitro and this migration of cells from animals sensitized to transplantation antigens is inhibited when the specific antigen is present1. Non-sensitized cells were not inhibited or exhibited a slight inhibition in similar conditions. This observation, comparable with results described by Al-Askari2,3, led to a study of the mechanism of the inhibition. In delayed hypersensitivity the release of a soluble protein substance from immune lymphocytes after stimulation with antigen has been demonstrated. This substance, termed migration inhibiting factor, has been shown to inhibit the migration of non-immune cells1,4-6,8,9. © 1969 Nature Publishing Group.