LIPOSOMES AND LOCAL HYPERTHERMIA - SELECTIVE DELIVERY OF METHOTREXATE TO HEATED TUMORS

被引:305
作者
WEINSTEIN, JN
MAGIN, RL
YATVIN, MB
ZAHARKO, DS
机构
[1] NCI,DIV CANC TREATMENT,CHEM PHARMACOL LAB,BETHESDA,MD 20014
[2] UNIV WISCONSIN,DEPT HUMAN ONCOL,RADIOBIOL RES LAB,MADISON,WI 53706
关键词
D O I
10.1126/science.432641
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Liposomes with phase transitions a few degrees above physiological temperature delivered more than four times as much methotrexate to in urine tumors heated to 42°C as to unheated control tumors. Most of the accumulated drug appeared to be intracellular and bound to dihydrofolate reductase, the enzyme blocked by methotrexate in its role as an antineoplastic agent. Copyright © 1979 AAAS.
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页码:188 / 191
页数:4
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