SELECTIVE EXPRESSION OF MURINE LYMPHOCYTE ALLOANTIGENS CONTROLLED BY THE X-CHROMOSOME

Alloantisera specific to X-chromosome linked lymphocyte membrane antigens (Ly-X) were prepared by immunizing F1 male mice with identical F1 female lymphocytes. Independent B cell specific (anti Lyb-X) and T cell specific (anti Lyt-X) antibodies were detected. The Lyt-X antigen was expressed on Lyt-2+, 3+, and on Tla-, Lyt-1+, 2+, 3+ T cell subpopulations. The problem of X-chromosome inactivation and the relationship of H-2-linked Ir genes and Ia antigens, with X-linked Ir genes and lymphocyte alloantigens are discussed. © 1979 Springer-Verlag New York Inc.