POTENT ANTIINFLAMMATORY ACTION OF CALCITONIN GENE-RELATED PEPTIDE

被引：92

作者：

RAUD, J

LUNDEBERG, T

BRODDAJANSEN, G

THEODORSSON, E

HEDQVIST, P

机构：

[1] KAROLINSKA INST,INST ENVIRONM MED,S-10401 STOCKHOLM 60,SWEDEN

[2] KAROLINSKA HOSP,S-10401 STOCKHOLM 60,SWEDEN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1991年 / 180卷 / 03期

关键词：

D O I：

10.1016/S0006-291X(05)81356-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Calcitonin gene-related peptide (CGRP), but not substance P (SP), was found to inhibit edema-promoting actions of inflammatory mediators (histamine, leukotrine B4, 5-hydroxytryptamine) in vivo in the hamster cheek pouch, human skin, and rat paw. The effect of CGRP was present in the low nanomolar dose range, and it was mimicked by activation of sensory nerves with capsaicin which caused release of endogenous CGRP-like immunoreactivity (IR). The findings provide new information on the potential impact of sensory nerve activation during inflammatory processes by indicating that sensory nerves may play an anti-inflammatory role. © 1991 Academic Press, Inc.

引用

页码：1429 / 1435

页数：7

共 23 条

[1] ENHANCEMENT OF THE BRONCHIAL REACTIVITY IN IMMUNIZED RATS BY NEONATAL TREATMENT WITH CAPSAICIN [J].