Data on clinical significance of GAS2 in colorectal cancer cells

被引：12

作者：

Chang, Chun-Chao ^{[1
,2
]}

Huang, Chi-Cheng ^{[3
,4
,5
]}

Yang, Shung-Haur ^{[6
,7
]}

Chien, Chih-Cheng ^{[3
,8
]}

Lee, Chia-Long ^{[3
,9
]}

Huang, Chi-Jung ^{[10
,11
]}

机构：

[1] Taipei Med Univ Hosp, Dept Internal Med, Div Gastroenterol & Hepatol, Taipei, Taiwan

[2] Taipei Med Univ, Sch Med, Coll Med, Dept Internal Med,Div Gastroenterol & Hepatol, Taipei, Taiwan

[3] Fu Jen Catholic Univ, Sch Med, New Taipei, Taiwan

[4] Cathay Gen Hosp, Breast Ctr, Taipei, Taiwan

[5] Taipei Med Univ, Sch Med, Taipei, Taiwan

[6] Taipei Vet Gen Hosp, Dept Surg, Taipei, Taiwan

[7] Natl Yang Ming Univ, Sch Med, Taipei, Taiwan

[8] Cathay Gen Hosp, Dept Anesthesiol, Taipei, Taiwan

[9] Cathay Gen Hosp, Dept Internal Med, Taipei, Taiwan

[10] Cathay Gen Hosp, Dept Med Res, Taipei, Taiwan

[11] Natl Def Med Ctr, Dept Biochem, Taipei, Taiwan

来源：

DATA IN BRIEF | 2016年 / 8卷

关键词：

D O I：

10.1016/j.dib.2016.05.010

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 [理学]; 0710 [生物学]; 09 [农学];

摘要：

The growth arrest-specific 2 (GAS2) was cloned and found to be upregulated in the feces of recurrent CRC patients. This over expressed GAS2 induced different patterns of gene expressions in CRC cells. Briefly, one cell proliferation marker, Ki-67 antigen (Ki-67), was upregulated in the cells with overexpressed GAS2, "Correlation between proliferation markers: PCNA, Ki-67, MCM-2 and antiapoptotic protein Bcl-2 in colorectal cancer" [1]. Whereas, the expression of another cell proliferation marker, proliferating cell nuclear antigen (PCNA), changed insignificantly [1]. In addition, the mRNA level of one cyclin involving in both cell cycle Gl/S and G2/M transitions was also not affected by GAS2 over expression, "Cdc20 and Cks direct the spindle checkpoint independent destruction of cyclin A" [2]. The experimental design and procedures in this article can be helpful for understanding the molecular significance of GAS2 in SW480 and SW620 CRC cells. (C) 2016 The Authors. Published by Elsevier lnc.

引用

页码：82 / 86

页数：5

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