EFFECT OF CLONIDINE ON THE CIRCULATION AND VASOACTIVE HORMONES AFTER AORTIC-SURGERY

被引：63

作者：

QUINTIN, L ^{[1
]}

ROUDOT, F ^{[1
]}

ROUX, C ^{[1
]}

MACQUIN, I ^{[1
]}

BASMACIOGULLARI, A ^{[1
]}

GUYENE, T ^{[1
]}

VAUBOURDOLLE, M ^{[1
]}

VIALE, JP ^{[1
]}

BONNET, F ^{[1
]}

GHIGNONE, M ^{[1
]}

机构：

[1] CHU MONDOR, DEPT ANESTHESIOL, CRETEIL, FRANCE

来源：

BRITISH JOURNAL OF ANAESTHESIA | 1991年 / 66卷 / 01期

关键词：

HORMONES; ADRENALINE; NORADRENALINE; RENIN; VASOPRESSIN; SURGERY; AORTIC; SYMPATHETIC NERVOUS SYSTEM; CLONIDINE;

D O I：

10.1093/bja/66.1.108

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

After completion of abdominal aortic graft, 29 patients received an i.v. infusion of placebo (n = 16) or clonidine 7-mu-g kg-1 (n = 13) over 120 min in a double-blind study. Cardiovascular variables were measured and plasma samples obtained up to 5 h after arrival in the recovery room, for assay of noradrenaline, adrenaline, vasopressin and renin concentrations. Noradrenaline, adrenaline and vasopressin concentrations decreased in the clonidine group throughout recovery (P < 0.001, 0.05 and 0.05, respectively, vs placebo). Heart rate was less in the clonidine group (P < 0.01). There was no significant difference in mean arterial pressure between groups. Stroke volume was larger (P < 0.01) and there were fewer episodes of hypertension (P < 0.05) and tachycardia in the clonidine group. In addition, a reduction in the number of circulatory interventions (P < 0.05) and episodes of shivering was noted in the clonidine group. Mean (SD) postoperative volume requirements were larger in the clonidine group (total postoperative input: clonidine 1462 (604) ml; placebo 1064 (348) ml (P < 0.05)). These data are consistent with the observation that clonidine modifies endocrine and circulatory status after major surgery.

引用

页码：108 / 115

页数：8

共 31 条

[1]

ANAND KJS, 1987, LANCET, V1, P243

[2] EFFECTS OF HYPOTENSION AND HYPOVOLEMIA ON LIBERATION OF VASOPRESSIN DURING HEMORRHAGE IN UNANESTHETIZED MONKEY (MACACA-MULATTA) [J].