SEROTONIN REINNERVATION OF THE RAT ORGANUM VASCULOSUM LAMINAE TERMINALIS (OVLT) AFTER 5,7-DIHYDROXYTRYPTAMINE DEAFFERENTATION

被引：9

作者：

SAIDI, H ^{[1
]}

BOSLER, O ^{[1
]}

机构：

[1] CNRS,NEUROBIOL LAB,EQUIPE NEUROMORPHOL FONCTIONNELLE,BP 71,F-13402 MARSEILLE 9,FRANCE

来源：

BRAIN RESEARCH | 1990年 / 530卷 / 01期

关键词：

5,7-Dihydroxytryptamine; Organum vasculosum laminae terminals; Radioautography; Regeneration; Serotonin; Ultrastructure;

D O I：

10.1016/0006-8993(90)90673-Y

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The time course and pattern of serotonin (5-HT) reinnervation in the rat organum vasculosum laminae terminalis (OVLT) following intracerebroventricular administration of 5,7-dihydroxytryptamine were examined by means of [3H]5-HT uptake radioautography. 5-HT axonal varicosities reappeared in the OVLT within 3 months post-lesion. Six monthslater, they were found to have preferentially reinvested the neurohemal contact area (juxtavascular zone) of the organ. Regenerated terminals further increased in number. At the end of a 16-month survival time, they displayed normal-looking distributional patterns similar to those of age-matched control animals, and formed new synaptic junctions in the juxtaventricular zone. The cellular mechanisms possibly responsible for 5-HT recovery in the OVLT are discussed. © 1990.

引用

页码：151 / 155

页数：5

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