AMPHOTERICIN VERSUS PENTAMIDINE IN ANTIMONY-UNRESPONSIVE KALA-AZAR

被引：105

作者：

MISHRA, M ^{[1
]}

BISWAS, UK ^{[1
]}

JHA, DN ^{[1
]}

KHAN, AB ^{[1
]}

机构：

[1] DARBHANGA MED COLL & HOSP,DEPT PATHOL,DARBHANGA 846003,BIHAR,INDIA

来源：

LANCET | 1992年 / 340卷 / 8830期

关键词：

D O I：

10.1016/0140-6736(92)92952-C

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We compared the efficacy of amphotericin B and pentamidine isethionate in a prospective randomised trial in 120 uncomplicated and parasitologically confirmed cases of antimony-unresponsive kala-azar. Doses were twenty intramuscular injections of pentamidine 4 mg/kg on alternate days or fourteen definitive doses of amphotericin 0.5 mg/kg infused in 5% dextrose on alternate days. 48 (80%) patients given pentamidine showed initial cure and 46 (77%) showed definitive cure compared with 60 (100%) and 59 (98%) cases, respectively, on amphotericin (p < 0.001). Amphotericin also brought about quicker abatement of fever and more complete spleen regression.

引用

页码：1256 / 1257

页数：2