MINISATELLITE REPEAT CODING AS A DIGITAL APPROACH TO DNA TYPING

被引：360

作者：

JEFFREYS, AJ

MACLEOD, A

TAMAKI, K

NEIL, DL

MONCKTON, DG

机构：

[1] Department of Genetics, University of Leicester, Leicester LE1 7RH, University Road

来源：

NATURE | 1991年 / 354卷 / 6350期

关键词：

D O I：

10.1038/354204a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Most DNA typing systems used in forensic and legal medicine assay allelic length variation at tandem repetitive DNA regions such as minisatellites. A simple alternative approach that displays patterns of variant repeat units along minisatellite alleles is described here. This produces DNA profiles as extraordinarily variable digital sequences appropriate for forensic investigations, including computer databasing, and for analysing allele diversity and the role of recombination in minisatellite instability.

引用

页码：204 / 209

页数：6

共 34 条

[1] ANALYSIS OF SOMATIC MUTATIONS AT HUMAN MINISATELLITE LOCI IN TUMORS AND CELL-LINES [J].