HUMAN PERIPHERAL-BLOOD LYMPHOCYTES EXPRESS D5 DOPAMINE RECEPTOR GENE AND TRANSCRIBE THE 2 PSEUDOGENES

被引：67

作者：

TAKAHASHI, N

NAGAI, Y

UENO, S

SAEKI, Y

YANAGIHARA, T

机构：

[1] OSAKA UNIV,SCH MED,DEPT NEUROL,1-1-50 FUKUSHIMA,FUKUSHIMA KU,OSAKA 553,JAPAN

[2] OSAKA UNIV,SCH MED,DEPT INTERNAL MED 2,FUKUSHIMA KU,OSAKA 553,JAPAN

来源：

FEBS LETTERS | 1992年 / 314卷 / 01期

关键词：

DOPAMINE RECEPTOR; LYMPHOCYTE; REVERSE TRANSCRIPTION; POLYMERASE CHAIN REACTION;

D O I：

10.1016/0014-5793(92)81452-R

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Sequential reverse transcription and polymerase chain reaction (RT-PCR) of the mRNA were used to investigate the expression of dopamine receptors in human peripheral blood lymphocytes. The RT-PCR products contained three types of sequences, each corresponding to those of the D5 dopamine receptor gene and the two related pseudogenes. The lymphocyte cDNA library also contained the clones encoding parts of the three genes. Binding profiles of dopaminergic ligands to the lymphocytes were similar to those for the native neuronal membranes.

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页码：23 / 25

页数：3

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