CONSTITUENTS OF CLINOPODIUM-UMBROSUM

The isolation and identification of fifteen crystalline components from the whole herb of Clinopodium umbrosum (Bieb.) C. Koch (Labiatae) are described. Their structures were determined on the basis of spectral evidence and chemical transformation. These compounds include five steroids (alpha-spinasterone, beta-sitosterol, stigmasterol, alpha-spinasterol, and alpha-spinasteryl-3-O-beta-glucopyranoside), four triterpenoids (3beta-hydroxyurs-11-en-28,13-olide, betulinic acid, oleanolic acid, ursolic acid), four flavonoids (luteolin, luteolin-7-O-beta-glucopyranoside, apigenin-7-O-beta-glucuronide, and apigenin-7-O-beta-methylglucuronate), and two lignolic acids [3-(3,4-dihydroxyphenyl)-lactic acid and rosmarinic acid].