EXPRESSION OF LYMPHOCYTES FC-EPSILON-RII/CD23 IN ALLERGIC CHILDREN UNDERGOING HYPOSENSITIZATION

被引:23
作者
GAGRO, A
RABATIC, S
TRESCEC, A
DEKARIS, D
MEDARLASIC, M
机构
[1] UNIV ZAGREB, INST IMMUNOL, ROCKEFELLER ST 10, ZAGREB 41000, CROATIA
[2] CHILDRENS HOSP TB & PULM DIS, ZAGREB, CROATIA
关键词
FC-EPSILON-RII/CD23; SCD23; LYMPHOCYTES; HYPOSENSITIZATION; CHILDREN; ALLERGIC ASTHMA; DERMATOPHAGOIDES-PTERONYSSINUS;
D O I
10.1159/000236520
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Owing to the proposed role of FcepsilonRII/CD23 in allergic diseases, we analyzed the expression of this receptor on peripheral blood lymphocytes (pan-B, pan-T and CD4+ or CD8+ T cells) and its autoproteolytic product sCD23 in serum. This was done in 10 asthmatic children allergic to Dermatophagoides pteronyssinus (Dpt) before and 6 weeks after hyposensitization. FACS analysis of double, direct immunofluorescence staining of the whole blood revealed an elevated percentage of FcepsilonRII/CD23+ lymphocytes in allergic children (10.29 +/- 5.0), a significantly higher percentage than in nonallergic children (5.7 +/- 2.4, p < 0.05). The majority of FcepsilonRII/CD23+ were on B cells. A significant positive correlation between the percentages of CD23+ lymphocytes and serum IgE levels was found (Spearman rank = 0.63, p < 0.05). The percentage of CD20+CD23+ lymphocytes significantly decreased after 6 weeks of hyposensitization (6.2 +/- 3.6, p < 0.05), while the percentage of CD20+ lymphocytes remained unchanged. Similarly, hyposensitization was followed by a reduction of total serum IgE levels, but Dpt-specific IgG4 and IgE remained unchanged.
引用
收藏
页码:203 / 208
页数:6
相关论文
共 32 条
[1]   EXPRESSION AND FUNCTIONAL-ROLE OF CD23 ON T-CELLS [J].
ARMITAGE, RJ ;
GOFF, LK ;
BEVERLEY, PCL .
EUROPEAN JOURNAL OF IMMUNOLOGY, 1989, 19 (01) :31-35
[2]   CD21 IS A LIGAND FOR CD23 AND REGULATES IGE PRODUCTION [J].
AUBRY, JP ;
POCHON, S ;
GRABER, P ;
JANSEN, KU ;
BONNEFOY, JY .
NATURE, 1992, 358 (6386) :505-507
[3]   HUMAN RECOMBINANT INTERLEUKIN-4 INDUCES FC-EPSILON RECEPTORS (CD23) ON NORMAL HUMAN LYMPHOCYTES-B [J].
DEFRANCE, T ;
AUBRY, JP ;
ROUSSET, F ;
VANBERVLIET, B ;
BONNEFOY, JY ;
ARAI, N ;
TAKEBE, Y ;
YOKOTA, T ;
LEE, F ;
ARAI, K ;
DEVRIES, J ;
BANCHEREAU, J .
JOURNAL OF EXPERIMENTAL MEDICINE, 1987, 165 (06) :1459-1467
[4]   THE LOW-AFFINITY RECEPTOR FOR IGE [J].
DELESPESSE, G ;
SARFATI, M ;
WU, CY ;
FOURNIER, S ;
LETELLIER, M .
IMMUNOLOGICAL REVIEWS, 1992, 125 :77-97
[5]   HUMAN IGE-BINDING FACTORS [J].
DELESPESSE, G ;
SARFATI, M ;
HOFSTETTER, H .
IMMUNOLOGY TODAY, 1989, 10 (05) :159-164
[6]  
EGGLESTON PA, 1988, PEDIATR CLIN N AM, V35, P1103
[7]   FC-RECEPTORS AND IMMUNOGLOBULIN BINDING-FACTORS [J].
FRIDMAN, WH .
FASEB JOURNAL, 1991, 5 (12) :2684-2690
[8]  
Gordon J, 1991, Monogr Allergy, V29, P156
[9]   EFFECTS OF IMMUNOTHERAPY ON THE EARLY, LATE, AND RECHALLENGE NASAL REACTION TO PROVOCATION WITH ALLERGEN - CHANGES IN INFLAMMATORY MEDIATORS AND CELLS [J].
ILIOPOULOS, O ;
PROUD, D ;
ADKINSON, NF ;
CRETICOS, PS ;
NORMAN, PS ;
KAGEYSOBOTKA, A ;
LICHTENSTEIN, LM ;
NACLERIO, RM .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1991, 87 (04) :855-866
[10]  
KAWABE T, 1988, J IMMUNOL, V141, P1376