A PATH-ANALYTICAL APPROACH TO DIFFERENTIATE BETWEEN DIRECT AND INDIRECT DRUG EFFECTS ON NEGATIVE SYMPTOMS IN SCHIZOPHRENIC-PATIENTS - A REEVALUATION OF THE NORTH-AMERICAN RISPERIDONE STUDY

被引:120
作者
MOLLER, HJ
MULLER, H
BORISON, RL
SCHOOLER, NR
CHOUINARD, G
机构
[1] UNIV BONN,DEPT PSYCHIAT,W-5300 BONN,GERMANY
[2] UNIV MONTREAL,LOUIS H LAFONTAINE HOSP,MONTREAL,PQ,CANADA
[3] MED COLL GEORGIA,DEPT PSYCHIAT & HLTH BEHAV,AUGUSTA,GA 30912
[4] UNIV PITTSBURGH,SCH MED,WESTERN PSYCHIAT INST & CLIN,PITTSBURGH,PA
关键词
NEUROLEPTICS; NEGATIVE SYMPTOMS; RISPERIDONE; SCHIZOPHRENIA; HALOPERIDOL;
D O I
10.1007/BF02191543
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The hypothesis that differences in drug effects of risperidone and haloperidol on negative symptoms in schizophrenia an secondary to effects on positive, extrapyramidal, and depressive symptoms was investigated by means of an analysis of the data from the USA-Canada risperidone double-blind randomized clinical trial of 523 chronic schizophrenic patients. Regression analyses in the total sample and within treatment groups confirmed a strong relationship between changes in negative symptoms and the other variables studied (R(2) = 0.50-0.51, p < 0.001). Only depressive symptoms did not contribute significantly to these results (p > 0.10). Path analysis showed that the greater mean change (p < 0.05) of negative symptoms with risperidone compared to haloperidol could not be fully explained by correlations with favourable effects on positive and extrapyramidal symptoms. The relationship between shift in extrapyramidal symptoms and shift in negative symptoms failed to reach statistical significance; however, there was a clear tendency in the expected direction in both treatment groups.
引用
收藏
页码:45 / 49
页数:5
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