EFFECT OF CYCLOSPORINE-A ON GLOMERULAR-FILTRATION RATE IN CHILDREN WITH MINIMAL CHANGE NEPHROTIC SYNDROME

被引：20

作者：

HULTON, SA

JADRESIC, L

SHAH, V

TROMPETER, RS

DILLON, MJ

BARRATT, TM

机构：

[1] Department of Paediatric Nephrology, The Hospital for Sick Children, London, WC1N 1EH, Great Ormond Street

[2] Medical Unit, Institute of Child Health, London, WC1N 1EH

来源：

PEDIATRIC NEPHROLOGY | 1994年 / 8卷 / 04期

关键词：

CYCLOSPORINE A; GLOMERULAR FILTRATION RATE; NEPHROTIC SYNDROME; NEPHROTOXICITY;

D O I：

10.1007/BF00856512

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Cyclosporin A (CyA) is now commonly used in the management of children with steroid-dependent nephrotic syndrome. In order to assess nephrotoxicity related to CyA therapy, we measured glomerular filtration rate (GFR) on 123 occasions in 24 children with minimal change nephrotic syndrome receiving CyA. GFR was estimated from the plasma clearance of (51)chromium-EDTA every 3 months during CyA therapy of up to 27 months duration. There was a significant reduction in GFR after 3 months of CyA therapy [118 +/- 33 (SD) to 93 +/- 24 ml/min per 1.73 m(2)] but no further fall thereafter, although the reduction in GFR was sustained for the duration of CyA therapy. This reduction in GFR appeared to be reversible upon cessation of CyA, but careful monitoring of renal function is necessary in such patients to prevent the development of longer term nephrotoxic sequelae.

引用

页码：404 / 407

页数：4

共 19 条

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