IMIDAZOLINES AS AMIDE BOND REPLACEMENTS

被引：42

作者：

GILBERT, IH

REES, DC

CROCKETT, AK

JONES, RCF

机构：

[1] ADDENBROOKES HOSP,PARKE DAVIS RES UNIT,CAMBRIDGE CB2 2QB,ENGLAND

[2] UNIV NOTTINGHAM,DEPT CHEM,NOTTINGHAM NG7 2RD,ENGLAND

来源：

TETRAHEDRON | 1995年 / 51卷 / 22期

关键词：

D O I：

10.1016/0040-4020(95)00273-B

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This work describes the use of a 2,5,5-trisubstituted imidazoline as an amide bond replacement The replacement is incorporated into dipeptide derivatives of Phe, Trp, Lys and Nle and also into the CCK-4 analogue Trp-Nle-Asp-Phe-NH2 and the pentagastrin analogue Gly-Trp-Nle-Asp-Phe-NH2. The amide bond replacement is synthesised in enantiomerically and diastereomerically pure form.

引用

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页码：6315 / 6336

页数：22

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