CHRONIC MUCOCUTANEOUS CANDIDIASIS AS A SURFACE EXPRESSION OF DEEP-SEATED ABNORMALITIES - REPORT OF A SYNDROME OF SUPERFICIAL CANDIDIASIS, ABSENCE OF DELAYED HYPERSENSITIVITY AND AMINOACIDURIA

Three patients with chronic mucocutaneous candidiasis have been studied. In the first patient, who also had an extensive skin infection due to Trichophyton rubrum, aminoaciduria and absence of delayed hypersensitivity to test antigens including oidiomycin were found. The coexistence of aminoaciduria and an immunologie abnormality has not been reported previously in a patient with chronic superficial candidiasis. The second patient had the following abnormalities: candidiasis, primary Addison's disease, enlarged thymus, miniscule spleen devoid of lymphoid tissue and lymphocytic infiltration of the thyroid gland. The third patient represents an example of the rare syndrome of familial juvenile keratoconjunctivitis, primary hypoparathyroidism, primary Addison's disease and superficial candidiasis. The patient who was lymphopenic lacked the addisonian component of the syndrome but had a sister who had the combination of hypoparathyroidism. Addison's disease and ovarian failure without associated candidiasis. Conditions favoring the development and persistence of chronic mucocutaneous candidiasis are discussed, with a review of the pertinent literature. © 1969.