NITROARGININE INHIBITS ENDOTHELIUM-DERIVED RELAXATION

被引：52

作者：

KOBAYASHI, Y ^{[1
]}

HATTORI, K ^{[1
]}

机构：

[1] SHIMANE MED UNIV,DEPT PHARMACOL,IZUMO,SHIMANE 693,JAPAN

来源：

JAPANESE JOURNAL OF PHARMACOLOGY | 1990年 / 52卷 / 01期

关键词：

D O I：

10.1254/jjp.52.167

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Effects of NG-nitro-L-arginine (NO2Arg), a guanidinonitro arginine derivative, on acetylcholine-induced relaxation of rabbit thoracic aorta ring preparation were studied. Relaxation by acetylcholine was inhibited by NO2Arg dose-dependently and the maximum relaxation with 102 µM NO Arg was reduced to 10.1±4.3% (n=5). L-arginine (102 µM) did not affect the acetylcholine-induced relaxation. Relaxation by glyceryltrinitrate or papaverine was not affected by NO2Arg. These results indicate that NO2Arg is a novel inhibitor of endothelium-derived relaxation. © 1990, The Japanese Pharmacological Society. All rights reserved.

引用

页码：167 / 169

页数：3

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