MICROINJECTIONS OF MUSCIMOL AND BICUCULLINE INTO THE PONTINE RETICULAR-FORMATION MODIFY THE SLEEP WAKING CYCLE IN THE RAT

被引：37

作者：

CAMACHOARROYO, I

ALVARADO, R

MANJARREZ, J

TAPIA, R

机构：

[1] NATL AUTONOMOUS UNIV MEXICO,INST FISIOL CELULAR,DEPT NEUROCIENCIAS,APARTADO POSTAL 70-600,MEXICO CITY 04510,DF,MEXICO

[2] INST NACL NEUROL & NEUROCIRUG,UNIDAD INVEST CEREBRALES,MEXICO CITY,MEXICO

来源：

NEUROSCIENCE LETTERS | 1991年 / 129卷 / 01期

关键词：

PONTINE RETICULAR FORMATION; SLEEP-WAKING CYCLE; MUSCIMOL; BICUCULLINE; GABAERGIC TRANSMISSION;

D O I：

10.1016/0304-3940(91)90728-C

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The role of gamma-aminobutyric acid (GABA) in the sleep-waking cycle was evaluated by means of microinjections of muscimol and bicuculline into the rat pontine reticular formation (PRF). Muscimol (20 ng) produced a marked increase in wakefulness (70%), a decrease in slow-wave sleep (SWS) (35%) and a remarkable delay in the onset of both SWS and paradoxical sleep, without modifying the percentage of the latter. Bicuculline (4 ng) shortened SWS latency by about 70%. These results suggest that GABAergic transmission in the PRF is involved in the regulation of sleep-waking cycle in the rat.

引用

页码：95 / 97

页数：3

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