NEUROBIOLOGY OF THE AGING BRAIN - MORPHOLOGICAL ALTERATIONS AT SYNAPTIC REGIONS

被引：9

作者：

BERTONIFREDDARI, C ^{[1
]}

FATTORETTI, P ^{[1
]}

CASOLI, T ^{[1
]}

PIERONI, M ^{[1
]}

MEIERRUGE, W ^{[1
]}

ULRICH, J ^{[1
]}

机构：

[1] UNIV BASEL,INST PATHOL,CH-4003 BASEL,SWITZERLAND

来源：

ARCHIVES OF GERONTOLOGY AND GERIATRICS | 1991年 / 12卷 / 2-3期

关键词：

NEUROBIOLOGY OF AGING; SYNAPTIC PLASTICITY; SYNAPTIC MORPHOMETRY; E-PTA; MITOCHONDRIA AND AGING; MORPHOMETRY OF MITOCHONDRIA; SYNAPTIC MITOCHONDRIA; CEREBELLUM; HIPPOCAMPUS;

D O I：

10.1016/0167-4943(91)90032-L

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Computer-assisted morphometric studies have been carried out on nerve cell terminal regions in rats of different ages. The numerical density (Nv), the average area (S) and the surface density (Sv) of ethanol phosphotungstic acid stained (E-PTA) synaptic junctions were evaluated in cerebellar glomeruli and dentate gyrus supragranular layers. The volume density (Vv), the average volume (V) and the numerical density (Nvm) of synaptic mitochondria were measured in the cerebellar glomeruli of young (3 months), adult (11 months) and old (28 months) animals. We found that during aging Nv and Sv undergo a significant decrease, whereas S is significantly increased. The mitochondrial Vv is unchanged in all the age groups analysed, whereas in old rats V is increased and Nvm decreased, respectively. We interpret our results as supporting that the old CNS retains part of its remodeling activity and is capable of adaptive morphological response at synaptic terminal regions.

引用

页码：253 / 259

页数：7

共 11 条

[1] QUANTITATIVE INVESTIGATION OF THE MORPHOLOGICAL PLASTICITY OF SYNAPTIC JUNCTIONS IN RAT DENTATE GYRUS DURING AGING [J].