CONCENTRATION-DEPENDENCE OF ADENOSINE AND THE PROTECTION OF RAT CORTICAL-NEURONS DURING ANOXIA

被引：8

作者：

DONAGHY, KM ^{[1
]}

SCHOLFIELD, CN ^{[1
]}

机构：

[1] QUEENS UNIV BELFAST,SCH BIOMED SCI,BELFAST BT9 7BL,ANTRIM,NORTH IRELAND

来源：

BRAIN RESEARCH | 1994年 / 656卷 / 01期

关键词：

ADENOSINE; ANOXIA; RAT; ISCHEMIA;

D O I：

10.1016/0006-8993(94)91380-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Aglycaemic/anoxic slices of rat olfactory cortex lose all electrical activity. On reoxygenation, 10 mu M adenosine enhanced recovery from 23 +/- 7% to 53 +/- 12%; an increased tissue endurance of 5-7 min. 100 mu M adenosine slightly depressed recovery to 11.5 +/- 2.1%. Dipyridamole increased whereas adenosine deaminase reduced recovery. These observations question the therapeutic effectiveness of high adenosine concentrations.

引用

页码：174 / 176

页数：3

共 19 条

[1]

BERNE RM, 1974, CIRC RES, V35, P265

[2]

Donaghy K, 1990, Neuroreport, V1, P123, DOI 10.1097/00001756-199010000-00010

[3]

DRUGANOW M, 1988, TRENDS PHARMACOL SCI, V9, P193

[4] PROTECTIVE EFFECT OF ADENOSINE AND A NOVEL XANTHINE DERIVATIVE PROPENTOFYLLINE ON THE CELL-DAMAGE AFTER BILATERAL CAROTID OCCLUSION IN THE GERBIL HIPPOCAMPUS [J].

DUX, E ;

FASTBOM, J ;

UNGERSTEDT, U ;

RUDOLPHI, K ;

FREDHOLM, BB .

BRAIN RESEARCH, 1990, 516 (02) :248-256

[5] HOW DOES ADENOSINE INHIBIT TRANSMITTER RELEASE [J].

FREDHOLM, BB ;

DUNWIDDIE, TV .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1988, 9 (04) :130-134

[6] ENDOGENOUS ADENOSINE DELAYS THE ONSET OF HYPOXIC DEPOLARIZATION IN THE RAT HIPPOCAMPUS INVITRO VIA AN ACTION AT A1 RECEPTORS [J].

LEE, KS ;

LOWENKOPF, T .

BRAIN RESEARCH, 1993, 609 (1-2) :313-315

[7] ADENOSINE-DEAMINASE FOR REMOVING ADENOSINE - HOW MUCH IS ENOUGH [J].

LINDEN, J .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1989, 10 (07) :260-262

[8] ROLE OF HYDROGEN-PEROXIDE IN THE CYTO-TOXICITY OF THE XANTHINE XANTHINE-OXIDASE SYSTEM [J].

LINK, EM ;

RILEY, PA .

BIOCHEMICAL JOURNAL, 1988, 249 (02) :391-399

[9] INVOLVEMENT OF ADENOSINE IN SYNAPTIC DEPRESSION INDUCED BY A BRIEF PERIOD OF HYPOXIA IN ISOLATED SPINAL-CORD OF NEONATAL RAT [J].

LLOYD, HGE ;

SPENCE, I ;

JOHNSTON, GAR .

BRAIN RESEARCH, 1988, 462 (02) :391-395

[10]

MCCORD JM, 1985, NEW ENGL J MED, V312, P159

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