DETECTION OF SEVERAL TYPES OF HUMAN PAPILLOMA VIRUSES IN AIDS-ASSOCIATED KAPOSIS-SARCOMA

被引:21
作者
ADAMS, V
KEMPF, W
HASSAM, S
BRINER, J
SCHMID, M
MOOS, R
PFALTZ, M
机构
[1] UNIV ZURICH, INST CLIN PATHOL, DEPT PATHOL, CH-8091 ZURICH, SWITZERLAND
[2] UNIV ZURICH HOSP, DEPT DERMATOL, CH-8091 ZURICH, SWITZERLAND
关键词
HUMAN PAPILLOMA VIRUS (HPV); EPIDEMIC KAPOSIS SARCOMA; AIDS; HPV TYPING; VIRUS; PCR; IN SITU HYBRIDIZATION;
D O I
10.1002/jmv.1890460304
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Epidemiological studies indicate that acquired immunodeficiency syndrome (AIDS)-associated Kaposi's sarcoma (KS) may be caused by an infectious, preferentially sexually transmitted agent. Infections with human papilloma viruses are common, sexually transmitted diseases occurring frequently in homosexual men, who are also the main risk group for developing KS. In order to evaluate the possible role of HPV in the development of KS, 24 cutaneous AIDS-associated Kaposi's sarcomas were investigated by the polymerase chain reaction (PCR) and by in situ hybridization for the presence of human papilloma viruses (HPV). HPV DNA sequences were detected in 5 of 24 KS specimens, in 4 of 13 normal skin specimens from AIDS patients without KS and in 5 of 14 skin specimens of HIV-seronegative patients. For the first time, HPV types 6 and 33 were detected by PCR in KS. A higher proportion of HPV types 16/18 was found in AIDS-associated KS specimens, whereas HPV type 33 was seen more often in normal skin specimens of the control group. Apart from the known HPV types 16/18 described in KS, this study demonstrates also the presence of HPV 6 and 33 in this condition. (C) 1995 Wiley-Liss, Inc.
引用
收藏
页码:189 / 193
页数:5
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