ACTIVATION OF D1 DOPAMINE-RECEPTORS STIMULATES THE RELEASE OF GABA IN THE BASAL GANGLIA OF THE RAT

被引：129

作者：

FLORAN, B ^{[1
]}

ACEVES, J ^{[1
]}

SIERRA, A ^{[1
]}

MARTINEZFONG, D ^{[1
]}

机构：

[1] INST POLITECN NACL,CTR INVEST & ESTUDIOS AVANZADOS,DEPT PHYSIOL BIOPHYS & NEUROSCI,MEXICO CITY 07000,DF,MEXICO

来源：

NEUROSCIENCE LETTERS | 1990年 / 116卷 / 1-2期

关键词：

Basal ganglia; D[!sub]1[!/sub] receptor; Dopamine; γ-Aminobutyric acid release;

D O I：

10.1016/0304-3940(90)90399-T

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Here we have explored whether dopamine is able to modulate the release of γ-aminobutyric acid (GABA) from striatal terminals to substantia nigra pars reticulata, entopeduncular nucleus, globus pallidus and caudate-putamen. The type of dopamine receptors involved was assessed by the blocking effect of either SCH 23390 (D1 antagonist) or (-)-sulpiride (D2 antagonist) of the dopamine effect. Dopamine stimulated (EC50 3.2 μM) the depolarization-induced release of [3H]GABA from slices isolated from all of the above mentioned nuclei. SCH 23390 dose-dependently blocked the dopamine stimulation, but (-)-sulpiride did not show any blocking effect. The results suggest that dopamine via D1 receptors modulates the release of GABA from striatal GABAergic terminals. © 1990.

引用

页码：136 / 140

页数：5

共 12 条

[1] DOPAMINE RELEASE INDUCED BY ELECTRICAL-STIMULATION OF MICRODISSECTED CAUDATE-PUTAMEN AND SUBSTANTIA NIGRA OF THE RAT-BRAIN [J].