SLIPPING PUMPS OR PROTON LEAKS IN OXIDATIVE-PHOSPHORYLATION - THE LOCAL-ANESTHETIC BUPIVACAINE CAUSES SLIP IN CYTOCHROME-C-OXIDASE OF MITOCHONDRIA

被引：29

作者：

VANDAM, K ^{[1
]}

SHINOHARA, Y ^{[1
]}

UNAMI, A ^{[1
]}

YOSHIDA, K ^{[1
]}

TERADA, H ^{[1
]}

机构：

[1] UNIV TOKUSHIMA,FAC PHARMACEUT SCI,TOKUSHIMA 770,JAPAN

来源：

FEBS LETTERS | 1990年 / 277卷 / 1-2期

关键词：

OXIDATIVE PHOSPHORYLATION; UNCOUPLING; MITOCHONDRIA; LOCAL ANESTHETIC; PROTON PUMP;

D O I：

10.1016/0014-5793(90)80826-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Evidence is presented to show that the local anesthetic bupivacaine causes slip in the mitochondrial proton pump cytochrome c oxidase.

引用

页码：131 / 133

页数：3

共 10 条

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