CHARACTERIZATION BY MONOCLONAL-ANTIBODY OF A HIGHLY CONSERVED ANTIGENIC DETERMINANT EXPRESSED ON HUMAN PLATELET MEMBRANES AND INTERMEDIATE FILAMENT TYPE-III

被引：2

作者：

ALESSIO, M

BELLONE, G

FUNARO, A

DEMONTE, LB

ROGGERO, S

PERUZZI, L

ZACCOLO, M

MOMO, M

CAPPA, APM

MALAVASI, F

机构：

[1] UNIV TURIN, DEPT GENET BIOL & MED CHEM, CELL BIOL LAB, I-10126 TURIN, ITALY

[2] CNR, NATL RES INST, CTR IMMUNOGENET & HISTOCOMPATIBIL, TURIN, ITALY

[3] ST GIOVANNI BATTISTA HOSP, SERV PATHOL HISTOL & ANAT, TURIN, ITALY

来源：

SCANDINAVIAN JOURNAL OF IMMUNOLOGY | 1990年 / 31卷 / 05期

关键词：

D O I：

10.1111/j.1365-3083.1990.tb02812.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The murine monoclonal antibody (MoAb) CB21, raised after immunization with sonicated extracts of human platelets, has been shown to react with a line‐restricted surface molecule and also a cytoplasmic structure displaying no restriction in terms of lineage and species. The surface structure recognized by the CB2I MoAb is exclusively expressed on the surface membrane of human platelets, being undetectabie on other cells or lines so far tested. After permeabilizalion. The majority of the cells and lines tested with the CB21 MoAb displayed strong cytoplasmic reactivity with a constant typical filamentous distribution. Biochemical and morphological analyses showed that the cytoplasmic counterpart recognized by the CB2I MoAb is the intermediate filament type III. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：609 / 617

页数：9

共 26 条

[1] ISOLATION OF THE THROMBOSPONDIN MEMBRANE-RECEPTOR [J].