CORTICONIGRAL DEGENERATION WITH NEURONAL ACHROMASIA - A CLINICOPATHOLOGICAL STUDY OF 2 CASES

被引：96

作者：

LIPPA, CF ^{[1
]}

SMITH, TW ^{[1
]}

FONTNEAU, N ^{[1
]}

机构：

[1] UNIV MASSACHUSETTS,MED CTR,DEPT NEUROL,WORCESTER,MA 01605

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 1990年 / 98卷 / 2-3期

关键词：

Achromasic neurons; Corticonigral degeneration; Magnetic resonance imaging (MRI); Movement disorder; Phosphorylated neurofilaments; Pick's disease;

D O I：

10.1016/0022-510X(90)90271-N

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We describe the clinical and neuropathological features of two patients having corticonigral degeneration with neuronal achromasia (CND). Both patients had cognitive decline and movement disorders. Magnetic resonance (MR) scans showed cortical atrophy, which in one case was most prominent in the parasylvian region, and ventricular enlargement in both cases. Neuropathological examination revealed swollen achromasic neurons within the cerebral cortex and marked neuronal loss in the substantia nigra. No Pick bodies, Lewy bodies, histologic changes of Alzheimer's disease, or spongiform change were present in either case. The diagnosis of CND should be considered in patients with complex movement disorders, with or without abnormalities in cognitive function. © 1990.

引用

页码：301 / 310

页数：10

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