INTERLEUKIN-1 PROTECTS FROM CYTOSINE ARABINOSIDE-INDUCED ALOPECIA IN THE RAT MODEL

被引：36

作者：

JIMENEZ, JJ

WONG, GHW

YUNIS, AA

机构：

[1] UNIV MIAMI,SCH MED,DEPT MED R38,POB 016960,MIAMI,FL 33101

[2] UNIV MIAMI,SCH MED,DEPT BIOCHEM & MOLEC BIOL,MIAMI,FL 33101

[3] UNIV MIAMI,SCH MED,DEPT ONCOL,MIAMI,FL 33101

[4] GENENTECH INC,SAN FRANCISCO,CA 94080

来源：

FASEB JOURNAL | 1991年 / 5卷 / 10期

关键词：

CHEMOTHERAPY; CYTOSINE ARABINOSIDE; ALOPECIA; CYTOKINES; INTERLEUKIN-1;

D O I：

10.1096/fasebj.5.10.2065892

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Protection from cytosine arabinoside-induced alopecia by ImuVert has recently been reported in a rat model. ImuVert, a biologic response modifier, is capable of activating mononuclear cells causing release of various cytokines. In the present study, using the young rat model, recombinant human IL l-beta produced excellent protection from cytosine arabinoside-induced alopecia. Mouse recombinant tumor necrosis factor gave definite but modest protection whereas human tumor necrosis factor gave none. It is concluded that the protection from alopecia by ImuVert is mediated by cytokines, primarily IL 1.

引用

页码：2456 / 2458

页数：3

共 11 条

[1]

ANSEL J, 1990, J INVEST DERMATOL, V94, P101

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