BRN-3.2 - A BRN-3-RELATED TRANSCRIPTION FACTOR WITH DISTINCTIVE CENTRAL-NERVOUS-SYSTEM EXPRESSION AND REGULATION BY RETINOIC ACID

被引:163
作者
TURNER, EE
JENNE, KJ
ROSENFELD, MG
机构
[1] UNIV CALIF SAN DIEGO, DEPT PSYCHIAT, LA JOLLA, CA 92093 USA
[2] UNIV CALIF SAN DIEGO, DEPT MED, LA JOLLA, CA 92093 USA
[3] UNIV CALIF SAN DIEGO, SCH MED, LA JOLLA, CA 92093 USA
基金
美国国家卫生研究院;
关键词
D O I
10.1016/0896-6273(94)90164-3
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The identification and molecular characterization of Brn-3.2 has revealed a family of Brn-3-related mammalian POU proteins that share homology with the C. elegans developmental regulator Unc-86 and extended similarity with the Drosophila neurodevelopmental gene I-POU, which defines a novel POU-IV box. Brn-3.2 exhibits DNA binding properties similar to those of Brn-3.0, but its expression is uniquely regulated by retinoic acid in teratocarcinoma and neuroblastoma cells. In the developing PNS and retina, the expression pattern of Brn-3.2 is similar to that of Brn-3.0. In the caudal CNS (spinal cord, hindbrain, and midbrain) Brn-3.2 and Brn-3.0 are initially coexpressed, but diverge later in development. Rostral to the midbrain, Brn-3.2 and Brn-3.0 exhibit nonoverlapping patterns of expression, suggesting divergence of gene function in more recently evolved structures. Our analysis suggests that in the CNS Brn-3.2 is selectively expressed in postmitotic neurons, implying a role in specifying terminally differentiated neuronal phenotypes.
引用
收藏
页码:205 / 218
页数:14
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