SHORT OPTIMALLY CAPPED DUPLEX DNA AS CONFORMATIONALLY RESTRICTED ANALOG OF B-DNA

被引：17

作者：

BANNWARTH, W ^{[1
]}

DORN, A ^{[1
]}

IAIZA, P ^{[1
]}

PANNEKOUKE, X ^{[1
]}

机构：

[1] LAB CHIM ORGAN SUBST NAT, F-67084 STRASBOURG, FRANCE

来源：

HELVETICA CHIMICA ACTA | 1994年 / 77卷 / 01期

关键词：

D O I：

10.1002/hlca.19940770121

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We describe the synthesis of short double-stranded DNA fragments (see 4 and 13) which are capped on both ends by an optimally designed linker molecule. The new structures are stable with respect to hybrid dissociation and should have implications in physical studies involving double-stranded DNA as well as in the antisense area for the specific modulation of gene expressions.

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页码：182 / 193

页数：12

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