REGIONAL ACCUMULATION OF AMYLOID BETA/A4 PROTEIN-PRECURSOR IN THE GERBIL BRAIN FOLLOWING TRANSIENT CEREBRAL-ISCHEMIA

被引：59

作者：

WAKITA, H ^{[1
]}

TOMIMOTO, H ^{[1
]}

AKIGUCHI, I ^{[1
]}

OHNISHI, K ^{[1
]}

NAKAMURA, S ^{[1
]}

KIMURA, J ^{[1
]}

机构：

[1] KYOTO UNIV HOSP,DEPT NEUROL,KYOTO 606,JAPAN

来源：

NEUROSCIENCE LETTERS | 1992年 / 146卷 / 02期

关键词：

AMYLOID BETA/A4 PROTEIN PRECURSOR; TRANSIENT CEREBRAL ISCHEMIA; NEURONAL VIABILITY;

D O I：

10.1016/0304-3940(92)90061-B

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Alterations of beta/A4 amyloid protein precursor (APP) were investigated immunohistochemically in the gerbil brain after transient global ischemia and subsequent reperfusion. Marked accumulation of this protein peaking at 24 h occurred in the neurons of the CA3 and paramedian region of the hippocampus as well as layers III, V and VI of the cerebral cortex. On the contrary, the accumulation was not observed in the neurons of the CA1 region. These results indicate that distribution of APP is altered depending on tissue viabilities after cerebral ischemia.

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页码：135 / 138

页数：4

相关论文

共 17 条

[1] INDUCTION OF HSP70 MESSENGER-RNA AFTER TRANSIENT ISCHEMIA IN GERBIL BRAIN [J].

ABE, K ;

TANZI, RE ;

KOGURE, K .

NEUROSCIENCE LETTERS, 1991, 125 (02) :166-168

[2] SELECTIVE INDUCTION OF KUNITZ-TYPE PROTEASE INHIBITOR DOMAIN-CONTAINING AMYLOID PRECURSOR PROTEIN MESSENGER-RNA AFTER PERSISTENT FOCAL ISCHEMIA IN RAT CEREBRAL-CORTEX [J].

ABE, K ;

TANZI, RE ;

KOGURE, K .

NEUROSCIENCE LETTERS, 1991, 125 (02) :172-174

[3] TROPHIC EFFECT OF BETA-AMYLOID PRECURSOR PROTEIN ON CEREBRAL CORTICAL-NEURONS IN CULTURE [J].

ARAKI, W ;

KITAGUCHI, N ;

TOKUSHIMA, Y ;

ISHII, K ;

ARATAKE, H ;

SHIMOHAMA, S ;

NAKAMURA, S ;

KIMURA, J .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1991, 181 (01) :265-271

[4] ALZHEIMERS-DISEASE - INITIAL REPORT OF THE PURIFICATION AND CHARACTERIZATION OF A NOVEL CEREBROVASCULAR AMYLOID PROTEIN [J].

GLENNER, GG ;

WONG, CW .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1984, 120 (03) :885-890

[5] THE PRECURSOR OF ALZHEIMERS-DISEASE AMYLOID-A4 PROTEIN RESEMBLES A CELL-SURFACE RECEPTOR [J].

KANG, J ;

LEMAIRE, HG ;

UNTERBECK, A ;

SALBAUM, JM ;

MASTERS, CL ;

GRZESCHIK, KH ;

MULTHAUP, G ;

BEYREUTHER, K ;

MULLERHILL, B .

NATURE, 1987, 325 (6106) :733-736

[6] EXPRESSION OF APP IN THE EARLY STAGE OF BRAIN-DAMAGE [J].

KAWARABAYASHI, T ;

SHOJI, M ;

HARIGAYA, Y ;

YAMAGUCHI, H ;

HIRAI, S .

BRAIN RESEARCH, 1991, 563 (1-2) :334-338

[7] DELAYED NEURONAL DEATH IN THE GERBIL HIPPOCAMPUS FOLLOWING ISCHEMIA [J].

KIRINO, T .

BRAIN RESEARCH, 1982, 239 (01) :57-69

[8] NOVEL PRECURSOR OF ALZHEIMERS-DISEASE AMYLOID PROTEIN SHOWS PROTEASE INHIBITORY ACTIVITY [J].

KITAGUCHI, N ;

TAKAHASHI, Y ;

TOKUSHIMA, Y ;

SHIOJIRI, S ;

ITO, H .

NATURE, 1988, 331 (6156) :530-532

[9] PRECURSOR OF AMYLOID PROTEIN IN ALZHEIMER-DISEASE UNDERGOES FAST ANTEROGRADE AXONAL-TRANSPORT [J].

KOO, EH ;

SISODIA, SS ;

ARCHER, DR ;

MARTIN, LJ ;

WEIDEMANN, A ;

BEYREUTHER, K ;

FISCHER, P ;

MASTERS, CL ;

PRICE, DL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (04) :1561-1565

[10] AMYLOID PRECURSOR PROTEIN IN AGED NONHUMAN-PRIMATES [J].

MARTIN, LJ ;

SISODIA, SS ;

KOO, EH ;

CORK, LC ;

DELLOVADE, TL ;

WEIDEMANN, A ;

BEYREUTHER, K ;

MASTERS, C ;

PRICE, DL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (04) :1461-1465