A GENERAL STRATEGY USING ETA-CO-2(2)(CO)(6) ACETYLENE COMPLEXES FOR THE SYNTHESIS OF THE ENEDIYNE ANTITUMOR AGENTS ESPERAMICIN, CALICHEAMICIN, DYNEMICIN AND NEOCARZINOSTATIN

被引：74

作者：

MAGNUS, P

机构：

[1] Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin

来源：

TETRAHEDRON | 1994年 / 50卷 / 05期

关键词：

D O I：

10.1016/S0040-4020(01)80626-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A review of the use of eta(2)Co(2)(CO)(6)-acetylene complexes as stable intermediates for the construction of the core structures of the antitumor enediyne agents esperamicin, calicheamicin, dynemicin and neocarzinostatin from the authors laboratory is presented.

引用

页码：1397 / 1418

页数：22

共 81 条

[1] REACTIVE 1,4-DEHYDROAROMATICS
BERGMAN, RG
[J]. ACCOUNTS OF CHEMICAL RESEARCH, 1973, 6 (01) : 25 - 31
[2] TOTAL SYNTHESIS OF CALICHEAMICINONE - A SOLUTION TO THE PROBLEM OF THE ELUSIVE URETHANE
CABAL, MP
COLEMAN, RS
DANISHEFSKY, SJ
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1990, 112 (08) : 3253 - 3255
[3] GENERATION AND CARBONYL ADDITION-REACTIONS OF Z-DILITHIOHEX-3-ENE-1,5-DIYNE
DANISHEFSKY, SJ
YAMASHITA, DS
MANTLO, NB
[J]. TETRAHEDRON LETTERS, 1988, 29 (37) : 4681 - 4684
[4] A CONCISE ROUTE TO THE CALICHEAMICIN-ESPERAMICIN SERIES - THE CRYSTAL-STRUCTURE OF A CORE SUBUNIT
DANISHEFSKY, SJ
MANTLO, NB
YAMASHITA, DS
SCHULTE, G
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1988, 110 (20) : 6890 - 6891
[5] CONCERNING 1,5-DIDEHYDRO[10]ANNULENE SYSTEM
DARBY, N
KIM, CU
SALAUN, JA
SHELTON, KW
TAKADA, S
MASAMUNE, S
[J]. JOURNAL OF THE CHEMICAL SOCIETY D-CHEMICAL COMMUNICATIONS, 1971, (23): : 1516 - &
[6] 2 DIVERSE MODES OF AROMATIZATION OF A NEW 10-MEMBERED RING ANALOG OF NEOCARZINOSTATIN CHROMOPHORE
FUJIWARA, K
KURISAKI, A
HIRAMA, M
[J]. TETRAHEDRON LETTERS, 1990, 31 (30) : 4329 - 4332
[7] ESPERAMICINS, A NOVEL CLASS OF POTENT ANTITUMOR ANTIBIOTICS .2. STRUCTURE OF ESPERAMICIN-X
GOLIK, J
CLARDY, J
DUBAY, G
GROENEWOLD, G
KAWAGUCHI, H
KONISHI, M
KRISHNAN, B
OHKUMA, H
SAITOH, K
DOYLE, TW
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1987, 109 (11) : 3461 - 3462
[8] ESPERAMICINS, A NOVEL CLASS OF POTENT ANTITUMOR ANTIBIOTICS .3. STRUCTURES OF ESPERAMICINS-A1, ESPERAMICIN-A2, AND ESPERAMICIN-A1B
GOLIK, J
DUBAY, G
GROENEWOLD, G
KAWAGUCHI, H
KONISHI, M
KRISHNAN, B
OHKUMA, H
SAITOH, K
DOYLE, TW
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1987, 109 (11) : 3462 - 3464
[9] EXPERIMENTAL MODELING OF THE PRIMING MECHANISM OF THE CALICHEAMICIN ESPERAMICIN ANTIBIOTICS - ACTUATION BY THE ADDITION OF INTRAMOLECULAR NUCLEOPHILES TO THE BRIDGEHEAD DOUBLE-BOND
HASELTINE, JN
DANISHEFSKY, SJ
SCHULTE, G
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1989, 111 (19) : 7638 - 7640
[10] TOTAL SYNTHESIS OF CALICHEAMICINONE - NEW ARRANGEMENTS FOR ACTUATION OF THE REDUCTIVE CYCLOAROMATIZATION OF AGLYCON CONGENERS
HASELTINE, JN
CABAL, MP
MANTLO, NB
IWASAWA, N
YAMASHITA, DS
COLEMAN, RS
DANISHEFSKY, SJ
SCHULTE, GK
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1991, 113 (10) : 3850 - 3866

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