TRANSDUCTION MECHANISMS INVOLVED IN THE REGULATION OF MYOGENIC ACTIVITY

被引:112
作者
DANGELO, G [1 ]
MEININGER, GA [1 ]
机构
[1] TEXAS A&M UNIV, HLTH SCI CTR,COLL MED,DEPT MED PHYSIOL, MICROCIRCULAT RES INST, COLLEGE STN, TX 77843 USA
关键词
HOMEOSTASIS; VASCULAR RESISTANCE; MUSCLE; SMOOTH; VASCULAR; VASOMOTOR SYSTEM;
D O I
10.1161/01.HYP.23.6.1096
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
Vascular smooth muscle has the ability to exist in a state of maintained partial constriction. This state of partial activation is initiated and/or maintained by the mechanical effects of distending pressure acting on the vascular wall. The intrinsic ability of vascular smooth muscle to respond to these mechanical forces is referred to as the myogenic mechanism. Within the past decade the signaling mechanisms responsible for mechanotransduction of myogenic phenomena have been the focus of extensive research. Two areas of active investigation include (1) the modulation of membrane ionic conductances by pressure/stretch and (2) the pressure/stretch - induced generation of second messengers known to be involved in vascular smooth muscle contraction. This review summarizes recent work aimed at understanding the mechanotransduction process in vascular smooth muscle.
引用
收藏
页码:1096 / 1105
页数:10
相关论文
共 123 条
[1]  
BARANY K, 1985, J BIOL CHEM, V260, P7126
[2]   STRETCH ACTIVATES MYOSIN LIGHT CHAIN KINASE IN ARTERIAL SMOOTH-MUSCLE [J].
BARANY, K ;
ROKOLYA, A ;
BARANY, M .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1990, 173 (01) :164-171
[3]   CHANNELS ACTIVATED BY STRETCH IN NEURONS OF A HELIX SNAIL [J].
BEDARD, E ;
MORRIS, CE .
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 1992, 70 (02) :207-213
[4]  
BENGUR AR, 1987, J BIOL CHEM, V262, P7613
[5]   CALCIUM-ACTIVATED POTASSIUM CHANNELS IN SINGLE SMOOTH-MUSCLE CELLS OF RABBIT JEJUNUM AND GUINEA-PIG MESENTERIC-ARTERY [J].
BENHAM, CD ;
BOLTON, TB ;
LANG, RJ ;
TAKEWAKI, T .
JOURNAL OF PHYSIOLOGY-LONDON, 1986, 371 :45-67
[6]  
BERRIDGE MJ, 1987, ANNU REV BIOCHEM, V56, P159, DOI 10.1146/annurev.bi.56.070187.001111
[8]   G-PROTEINS AND THE MECHANISM OF ACTION OF HORMONES, NEUROTRANSMITTERS, AND AUTOCRINE AND PARACRINE REGULATORY FACTORS [J].
BIRNBAUMER, L ;
BROWN, AM .
AMERICAN REVIEW OF RESPIRATORY DISEASE, 1990, 141 (03) :S106-S114
[9]  
BORST JGG, 1963, LANCET, V1, P677
[10]   REGULATION OF ARTERIAL TONE BY ACTIVATION OF CALCIUM-DEPENDENT POTASSIUM CHANNELS [J].
BRAYDEN, JE ;
NELSON, MT .
SCIENCE, 1992, 256 (5056) :532-535