SYNTHESIS AND STRUCTURE - ANTI-TUMOR-PROMOTING ACTIVITY RELATIONSHIP OF MONOGALACTOSYL DIACYLGLYCEROLS

被引：43

作者：

NAGATSU, A

WATANABE, M

IKEMOTO, K

HASHIMOTO, M

MURAKAMI, N

SAKAKIBARA, J

TOKUDA, H

NISHINO, H

IWASHIMA, A

YAZAWA, K

机构：

[1] NAGOYA CITY UNIV,FAC PHARMACEUT SCI,MIZUHO KU,NAGOYA,AICHI 467,JAPAN

[2] KYOTO PREFECTURAL UNIV MED,DEPT BIOCHEM,KAMIGYO KU,KYOTO 602,JAPAN

[3] SAGAMI CHEM RES CTR,SAGAMIHARA,KANAGAWA 229,JAPAN

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 13期

关键词：

D O I：

10.1016/S0960-894X(01)80577-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Monogalactosyl diacylglycerols (MGDG, 1a-t) were synthesized utilizing p-methoxybenzyl group for protection of hydroxyl groups at sugar moiety. Inhibitory activity of MGDG (la-t) and related compounds on Epstein-Barr virus early antigen activation was evaluated as anti-tumor-promoting activity, and MGDG with oleoyl group (1c,h-j,ps) showed strong activity.

引用

页码：1619 / 1622

页数：4

共 15 条

[1]

FLETCHER HG, 1963, METHODS CARBOHYDR CH, V2, P226

[2] SYNTHESIS OF 1,2-DI-O-HEXADECANOYL-3-O-(BETA-D-GALACTOPYRANOSYL)-L-GLYCEROL (A GALACTOSYL-DIGLYCERIDE) AND 1,2-DI-O-OCTADECANOYL-3-O-(6-O-OCTADECANOYL-BETA-D-GALACTOPYRANOSYL)-L-GLYCEROL [J].