IMMUNE-RESPONSE TO INFLUENZA VACCINATION IN CHILDREN WITH RENAL-DISEASE

被引：32

作者：

FURTH, SL ^{[1
]}

NEU, AM ^{[1
]}

MCCOLLEY, SA ^{[1
]}

CASE, B ^{[1
]}

STEINHOFF, M ^{[1
]}

FIVUSH, B ^{[1
]}

机构：

[1] JOHNS HOPKINS UNIV,SCH MED,DIV PEDIAT NEPHROL,BALTIMORE,MD

来源：

PEDIATRIC NEPHROLOGY | 1995年 / 9卷 / 05期

关键词：

INFLUENZA; IMMUNIZATION; PEDIATRIC RENAL DISEASE; DIALYSIS; TRANSPLANT;

D O I：

10.1007/BF00860934

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Although immunization with influenza vaccine is recommended for children with chronic renal disease and after organ transplantation, the antibody response in these children has not been well described. We studied the response to the 1993-1994 trivalent influenza vaccine in children, aged 1-21 years, with chronic renal failure (n=15), end-stage renal disease requiring dialysis (n=10), and post renal transplantation (n=17). Each group's antibody response was compared with that of a control group (n=7). No significant differences were found in seroconversion rates, percentage of patients achieving protective hemagglutination-inhibition titers post vaccination or change in geometric mean titers from pre to post vaccination between study groups and controls. These results suggest that pediatric patients with renal disease will respond and therefore will benefit from currently recommended influenza immunization.

引用

页码：566 / 568

页数：3

共 13 条

[1]

Mauch T., Freese D., Braumlin E., Dunn D., Crouch N., Kashton C., Immunization of pediatric solid organ transplant recipients against influenza B, J Am Soc Nephrol, 4, (1993)

[2]

Mauch T., Bratton S., Myers T., Krane E., Gentry S., Kashtan C., Influenza B virus infection in pediatric solid organ transplant recipients, Pediatrics, 94, pp. 225-229, (1994)

[3]

Beyer W.E.P., Noordzij T.C., Kramer P., Diderich P.P.M.N., Op den Hoek C.T., Janssen J., Masurel N., Weimar W., Effect of immunomodulator thymopentin on impaired seroresponse to influenza vaccine in patients on haemodialysis, Nephron, 54, pp. 296-301, (1990)

[4]

Steele R.W., Current status of vaccines and immune globulins for children with renal disease, Pediatr Nephrol, 8, pp. 7-10, (1994)

[5]

Schwartz G.J., Haycock J.B., Edelman C.M., Spitzer A., A simple estimate of glomerular filtration rate in children derived from body length and plasma creatinine, Pediatrics, 58, pp. 259-263, (1976)

[6]

Schwartz G.J., Brion L.P., Spitzer A., The use of plasma creatinine concentration for estimating GFR in infants, children and adolescents, Pediatr Clin North Am, 34, pp. 571-591, (1987)

[7]

Madore H.P., Reichman R.C., Dolin R., Serum antibody responses in naturally occurring influenza A virus infection determined by enzyme linked immunosorbent assay, hemagglutination inhibition, and complement fixation, J Clin Microbiol, 18, pp. 1345-1350, (1983)

[8]

Zuckerman M., Haaheim L., Activity of influenza vaccine against virus strains now circulating, Lancet, 339, (1992)

[9]

SAS language and procedures: usage, version 6, (1989)

[10]

Gruber W.C., Taber L.H., Glezen W.P., Clover R.D., Abell T.D., Demmler R.W., Couch R.B., Live attenuated and inactivated influenza vaccine in school-age children, Am J Dis Child, 144, pp. 595-600, (1990)

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