ANALYSIS OF JUNCTIONAL DIVERSITY DURING LYMPHOCYTE-B DEVELOPMENT

被引：113

作者：

MEEK, K

机构：

[1] Department of Internal Medicine, Division of Rheumatology, University of Texas Southwestern Medical Center, Dallas

来源：

SCIENCE | 1990年 / 250卷 / 4982期

关键词：

D O I：

10.1126/science.2237433

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Immunoglobulin rearrangement is central to generating antibody diversity because of heterogeneity generated during recombination by deletion or addition of nucleotides at coding joints by the recombinase machinery. Examination of these junctional modifications revealed that the addition of nongermline-encoded nucleotides was more prevalent in adult versus fetal B cells, thus partially limiting the fetal antibody repertoire. In contrast, deletion of nucleotides occurs equivalentiy in B cells at different stages of development and at different points in B cell ontogeny. Finally, the bias in murine immunoglobulins for one DH segment reading frame occurs at the DHJ H intermediate.

引用

页码：820 / 823

页数：4

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