STUDIES ON A NEW ANTIMALARIAL COMPOUND - PYRONARIDINE

被引：85

作者：

CHEN, C

TANG, LH

JANTANAVIVAT, C

机构：

[1] MAHIDOL UNIV, FAC TROP MED, DEPT PROTOZOOL, BANGKOK 10400, THAILAND

[2] CHINESE ACAD PREVENT MED, INST PARASIT DIS, SHANGHAI 200025, PEOPLES R CHINA

来源：

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE | 1992年 / 86卷 / 01期

关键词：

D O I：

10.1016/0035-9203(92)90414-8

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Pyronaridine, a hydroxyanilino-benzonaphthyridine derivative synthesized in 1970, is a new antimalarial compound which has been in use in China for more than 10 years. The drug is highly effective against Plasmodium falciparum and P. vivax. Furthermore, it is efficacious in combatting chloroquine-resistant strains of falciparum malaria both in vitro and in vivo, in human patients. Extensive field studies involving several thousand cases have shown that pyronaridine has promising therapeutic value in the treatment of malarial infection, including chloroquine-resistant infections. Pyronaridine given orally, intramuscularly or by intravenous drip is not only effective against malaria but also has low toxicity.

引用

页码：7 / 10

页数：4

共 39 条

[1]

Cai XZ, 1987, CHIN J PARASITOL PAR, V5, P228

[2]

Che L G, 1984, Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi, V2, P280

[3]

Che L. G., 1990, Chinese Journal of Parasitic Disease Control, V3, P24

[4]

CHE LG, 1987, J PARASITOLOGY PARAS, V6, P194

[5]

CHEN C, 1981, PHARM IND, V9, P12

[6] INVITRO ACTIVITY OF PYRONARIDINE AGAINST FIELD ISOLATES AND REFERENCE CLONES OF PLASMODIUM-FALCIPARUM [J].

CHILDS, GE ;

HAUSLER, B ;

MILHOUS, W ;

CHEN, C ;

WIMONWATTRAWATEE, T ;

POOYINDEE, N ;

BOUDREAU, EF .

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1988, 38 (01) :24-29

[7]

DAI ZR, 1986, ACAD J SEC MILIT MED, V7, P265

[8]

FENG Z, 1987, ACTA PHARM SINIC, V8, P543

[9]

FENG Z, 1986, ACTA PHARMACOL SINIC, V21, P801

[10]

Huang Z S, 1988, Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi, V6, P285

← 1 2 3 4 →