INTERACTION OF CHOLESTEROL-CONJUGATED ALKYLATING OLIGONUCLEOTIDE DERIVATIVES WITH CELLULAR BIOPOLYMERS

被引：21

作者：

RYTE, AS

KARAMYSHEV, VN

NECHAEVA, MV

GUSKOVA, ZV

IVANOVA, EM

ZARYTOVA, VF

VLASSOV, VV

机构：

[1] Institute of Bioorganic Chemistry, Siberian Division, the USSR Academy of Sciences, Novosibirsk

来源：

FEBS LETTERS | 1992年 / 299卷 / 02期

关键词：

OLIGONUCLEOTIDE DERIVATIVE; CELLULAR UPTAKE; AFFINITY MODIFICATION;

D O I：

10.1016/0014-5793(92)80229-A

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Interactions of oligonucleotide derivatives with mammalian cells and cellular biopolymers have been investigated. The derivatives were oligonucleotides bearing an alkylating 2-chloroethylamino group at the 3'-end and a cholesterol residue at the 5'-terminal phosphate. These compounds are readily taken up by cells and react with cellular DNA, RNA and some proteins which may play a role in delivery of the compounds into cells.

引用

页码：124 / 126

页数：3

共 16 条

[1] COMPLEMENTARY ADDRESSED MODIFICATION OF NUCLEIC-ACIDS WITH THE ALKYLATING DERIVATIVES OF OLIGOTHYMIDYLATE ETHYL PHOSPHOTRIESTERS - EFFECT OF THE PHOSPHOTRIESTER FRAGMENTS CONFIGURATION [J].