MOLECULAR-BASIS FOR THE ASSOCIATION BETWEEN HLA DR4 AND RHEUMATOID-ARTHRITIS - FROM THE SHARED EPITOPE HYPOTHESIS TO A PEPTIDIC MODEL OF RHEUMATOID-ARTHRITIS

被引：20

作者：

ALBANI, S

ROUDIER, J

机构：

[1] UNIV CALIF SAN DIEGO,SCH MED,INST AGING,LA JOLLA,CA 92037

[2] FAC MED MARSEILLE,IMMUNORHUMATOL LAB,F-13005 MARSEILLE,FRANCE

来源：

CLINICAL BIOCHEMISTRY | 1992年 / 25卷 / 03期

关键词：

HLA-DR4; RHEUMATOID ARTHRITIS; T-CELL REPERTOIRE; SELF-PEPTIDE;

D O I：

10.1016/0009-9120(92)90328-P

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Susceptibility to rheumatoid arthritis (RA) maps to residues QKRAA/QRRAA in the third hypervariable region of the HLA DR-beta-1 chain. Peptides from the same area of MHC class II molecules are able to modulate the T-cell repertoire by deleting self-reactive T-cells. The Epstein Barr virus glycoprotein gp110 and the dna J heat-shock protein from E. coli mimic the third hypervariable region of HLA-Dw4DR-beta-1. Thus, the same area of HLA DR-beta-1 carries susceptibility to RA, modulates the T-cell repertoire and is mimicked by human pathogens. RA may originate from a particular shape imposed on the T-cell repertoire by the QKRAA/QRRAA sequence in the third hypervariable region of HLA DR-beta-1.

引用

页码：209 / 212

页数：4

共 16 条

[1] THE SUSCEPTIBILITY SEQUENCE TO RHEUMATOID-ARTHRITIS IS A CROSS-REACTIVE B-CELL EPITOPE SHARED BY THE ESCHERICHIA-COLI HEAT-SHOCK PROTEIN DNAJ AND THE HISTOCOMPATIBILITY LEUKOCYTE ANTIGEN DRB10401 MOLECULE [J].