ATRIAL-NATRIURETIC-PEPTIDE AND ANTIHYPERTENSIVE ACTION DUE TO BETA-BLOCKADE IN ESSENTIAL HYPERTENSIVE PATIENTS

被引:13
作者
HAMA, J
NAGATA, S
TAKENAKA, T
KINO, H
KAMOI, K
SHIMADA, S
HORIUCHI, M
KATORI, R
机构
[1] Department of Internal Medicine, University School of Medicine, Osaka
关键词
D O I
10.1177/000331979504600608
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
The effects of beta-blocker treatment on hemodynamics were studied in relation to plasma atrial natriuretic peptide (ANP) levels in 17 outpatients with essential hypertension. Administration of propranolol for twelve weeks to untreated subjects resulted in a significant (P < 0.001) rise in plasma ANP levels (from 37.9 +/- 21.2 to 66.7 +/- 46.2 pg/mL, mean +/- SD). Systolic and diastolic blood pressures were significantly decreased (P < 0.05 and P < 0.01, respectively). Heart rate was also significantly decreased (P < 0.001). On the other hand, a significant reduction of cardiac index was detected (from 4.12 +/- 1.34 to 2.96 +/- 0.75 L/min/m(2), P < 0.01) with chronic administration of propranolol, suggesting a reflection of decreased cardiac function. A significant negative correlation was observed between %changes in systolic blood pressure and %changes in plasma ANP (r=-0.594, P < 0.05). These results suggest that the increased plasma ANP levels may contribute to the antihypertensive effect with propranolol.
引用
收藏
页码:511 / 516
页数:6
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