OBSERVATIONS ON CENTRAL CONTROL OF DRINKING AND OF RELEASE OF ANTIDIURETIC HORMONE (ADH)

The thirst response to slow infusions of hypertonic NaCl into different parts of the 3rd brain ventricle of the goat was studied. The most efficient stimulation of the thirst mechanism was obtained by infusions into the anterior ventral part of the ventricle. Repeated brief infusions of hypertonic NaCl into this part of the 3rd ventricle gave a very consistent antidiuretic response in hydrated goats. Direct evidence that this antidiuresis was due to a release of endogenous ADH was obtained by the observation that the response disappeared when experimental diabetes insipidus had been produced. © 1969.