TEMPERATURE AND VOLTAGE DEPENDENCE OF SODIUM-CHANNEL BLOCKING AND UNBLOCKING BY O-DEMETHYL ENCAINIDE IN ISOLATED GUINEA-PIG MYOCYTES

被引：31

作者：

JOHNS, JA

ANNO, T

BENNETT, PB

SNYDERS, DJ

HONDEGHEM, LM

机构：

[1] VANDERBILT UNIV,MED CTR,SCH MED,DEPT MED,NASHVILLE,TN 37232

[2] VANDERBILT UNIV,MED CTR,SCH MED,DEPT PHARMACOL,NASHVILLE,TN 37232

[3] VANDERBILT UNIV,MED CTR,SCH MED,DEPT PEDIAT,NASHVILLE,TN 37232

来源：

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY | 1989年 / 13卷 / 06期

关键词：

D O I：

10.1097/00005344-198906000-00004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：826 / 835

页数：10

共 25 条

[1] ANTIARRHYTHMIC ACTIVITY, ELECTROCARDIOGRAPHIC EFFECTS AND PHARMACOKINETICS OF THE ENCAINIDE METABOLITES O-DESMETHYL ENCAINIDE AND 3-METHOXY-O-DESMETHYL ENCAINIDE IN MAN [J].

BARBEY, JT ;

THOMPSON, KA ;

ECHT, DS ;

WOOSLEY, RL ;

RODEN, DM .

CIRCULATION, 1988, 77 (02) :380-391

[2] RESTING AND RATE-DEPENDENT DEPRESSION OF MAXIMUM RATE OF DEPOLARIZATION (VMAX) IN GUINEA-PIG VENTRICULAR ACTION-POTENTIALS BY MEXILETINE, DISOPYRAMIDE, AND ENCAINIDE [J].

CAMPBELL, TJ .

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 1983, 5 (02) :291-296

[3] KINETICS OF ONSET OF RATE-DEPENDENT EFFECTS OF CLASS-I ANTI-ARRHYTHMIC DRUGS ARE IMPORTANT IN DETERMINING THEIR EFFECTS ON REFRACTORINESS IN GUINEA-PIG VENTRICLE, AND PROVIDE A THEORETICAL BASIS FOR THEIR SUBCLASSIFICATION [J].

CAMPBELL, TJ .

CARDIOVASCULAR RESEARCH, 1983, 17 (06) :344-352

[4] SODIUM CURRENT IN SINGLE CELLS FROM BULLFROG ATRIUM - VOLTAGE DEPENDENCE AND ION TRANSFER PROPERTIES [J].

CLARK, RB ;

GILES, W .

JOURNAL OF PHYSIOLOGY-LONDON, 1987, 391 :235-265

[5] VOLTAGE CLAMP MEASUREMENTS OF SODIUM-CHANNEL PROPERTIES IN RABBIT CARDIAC PURKINJE-FIBERS [J].

COLATSKY, TJ .

JOURNAL OF PHYSIOLOGY-LONDON, 1980, 305 (AUG) :215-234

[6] FAST FREQUENCY-DEPENDENT BLOCK OF ACTION POTENTIAL UPSTROKE IN RABBIT ATRIUM BY SMALL LOCAL-ANESTHETICS [J].

COURTNEY, KR .

LIFE SCIENCES, 1979, 24 (17) :1581-1588

[7]

ELHARRAR V, 1982, J PHARMACOL EXP THER, V220, P440

[8]

Eyring H., 1949, REC CHEM PROGR, V100, P100

[9]

FOLLMER CH, 1987, J PHARMACOL EXP THER, V243, P187

[10]

FOZZARD HA, 1986, J PHYSIOL-LONDON, V371, pP194

← 1 2 3 →