DETERMINATION OF PLASMA NEFOPAM BY LIQUID-CHROMATOGRAPHY AND ELECTROCHEMICAL DETECTION

被引：10

作者：

BURTON, LC ^{[1
]}

LOFTUS, NJ ^{[1
]}

VERE, DW ^{[1
]}

WHELPTON, R ^{[1
]}

机构：

[1] UNIV LONDON LONDON HOSP,COLL MED,DEPT PHARMACOL & THERAPEUT,LONDON E1 2AD,ENGLAND

来源：

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1990年 / 526卷 / 01期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/S0378-4347(00)82493-7

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A liquid chromatographic method for the determination of plasma nefopam is presented. A combination of liquid- and solid-phase extraction and electrochemical detection gave clean extracts and, hence, a low limit of detection. Calibration curves were linear over at least two orders of magnitude (1-100 ng/ml) making the method suitable for pharmacokinetic studies. © 1990.

引用

页码：159 / 168

页数：10

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