THE EFFECTS OF EXOGENOUS GLUTATHIONE AND CYSTEINE ON OXIDATIVE STRESS-INDUCED BY FERRIC NITRILOTRIACETATE

被引：15

作者：

UMEMURA, T ^{[1
]}

SAI, K ^{[1
]}

TAKAGI, A ^{[1
]}

HASEGAWA, R ^{[1
]}

KUROKAWA, Y ^{[1
]}

机构：

[1] NATL INST HYG SCI,DIV TOXICOL,SETAGAYA KU,TOKYO 158,JAPAN

来源：

CANCER LETTERS | 1991年 / 58卷 / 1-2期

关键词：

GLUTATHIONE; CYSTEINE; OXIDATIVE STRESS; 8-HYDROXYDEOXYGUANOSINE; FERRIC NITRILOTRIACETATE;

D O I：

10.1016/0304-3835(91)90022-A

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The effects of the antioxidants, glutathione (GSH) and its precursor cysteine (Cys) on oxidative damage induced by ferric nitrilotriacetate (Fe-NTA) were examined. Fe-NTA-associated oxidative stress caused the depletion of renal cellular GSH content. Administration of exogenous GSH and Cys suppressed 8-hydroxydeoxyguanosine (8-OH-dG) formation, an indicator of oxidative DNA damage and nephrotoxicity following Fe-NTA treatment. This suggests that generation of free radicals may be causally involved in oxidative lesion generation. Since lipid peroxidation was found to be inhibited only by GSH and not Cys treatment, this suggests that this effect and the DNA damage might be mediated by different pathways. Fe-NTA-associated oxidative stress in renal tubular cells might thus operate via both intracellular and external space modes.

引用

页码：49 / 56

页数：8

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